Correlation Analysis of Silent Information Modulator 3 and TCM Dampness Syndrome Score with Uremic Cardiomyopathy

OBJECTIVE To investigate the relationship between silent information modulator 3 (SIRT3) and TCM dampness syndrome score with uremic cardiomyopathy (UCM).

METHODS A total of 202 patients with end-stage renal disease (ESRD) undergoing regular dialysis who visited the First People’s Hospital of Lianyungang from September 2024 to November 2025 were selected. According to the inclusion and exclusion criteria, 129 patients were enrolled in the UCM group and 73 in the non-UCM group, respectively. General clinical data, serum SIRT3 levels, and TCM dampness syndrome scores were collected and analyzed for both groups. Spearman correlation analysis was used to analyze the correlation between each observation indicator and SIRT3 levels and TCM dampness syndrome scores. Logistic regression model was used to analyze risk factors for UCM, and receiver operating characteristic (ROC) curves were plotted to assess the diagnostic value of each risk factor for UCM.

RESULTS Compared with the non-UCM group, the UCM group had a significantly higher proportion of female patients, as well as those with renal hypertension, complicated coronary heart disease and cardiac insufficiency. Meanwhile, the levels of glycated hemoglobin (HbA1c), B-type natriuretic peptide (BNP) and TCM dampness syndrome score were markedly elevated, whereas the SIRT3 level was decreased (all P<0.05). Spearman correlation analysis revealed that serum SIRT3 was negatively correlated with left ventricular mass index (LVMI), left ventricular end-diastolic dimension (LVEDD) and interventricular septum thickness (IVST) (r_s=-0.556, P<0.001; r_s=-0.366, P<0.001; r_s=-0.333, P<0.001). Logistic regression analysis showed that female odds ratio (OR)=2.796, 95% confidence interval (CI): 1.172–6.671, P<0.05, low SIRT3 (OR=0.041, 95% CI: 0.012–0.133), and high TCM dampness syndrome score (OR=1.032, 95% CI: 1.000–1.065) were strongly associated with the incidence of UCM (P<0.05). ROC curve analysis demonstrated that the area under the ROC curve (AUC) of serum SIRT3 was 0.901 (95% CI: 0.846–0.957); the AUC of TCM dampness syndrome score was 0.642 (95% CI: 0.563–0.721); and the combined AUC of both was 0.906 (95% CI: 0.853–0.958).

CONCLUSION Serum SIRT3 is independently associated with the risk of UCM. The combined efficacy of TCM dampness syndrome score and SIRT3 in predicting UCM is better and can provide a reference for UCM prediction.